@article{ref1,
title="[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission]",
journal="Japanese journal of toxicology",
year="2006",
author="Inoue, Shigeaki and Yamamoto, Isotoshi and Akieda, Kazuki and Sekiguchi, Hiroshi and Otuka, Hiroyuki and Morita, Seiji and Nakagawa, Yoshihide and Inokuchi, Sadaki",
volume="19",
number="3",
pages="265-271",
abstract="A 41-year-old female attempted suicide by taking 7.8g acetaminophen and was transferred to our hospital four hours after ingestion. The patient was diagnosed as non-hepatic toxicity (below the line set by the Rumack Matthew nomogram). Laboratory data showed an elevation in serum liver enzymes and coagulation defects at 3 days after ingestion, therefore, the patient was treated with plasma exchange and an oral administration of N-acetylcysteine (NAC). The elevation of liver enzymes was maximal at 4 days after ingestion, and the laboratory data became normalized at approximately 9 days after ingestion. In this case, habitual alcohol intake may have exacerbated the severe liver injury. We should consider an exacerbation of hepatotoxicity and administer NAC in any case having a history of habitual alcohol intake, even if the case was diagnosed as non-hepatic toxicity by the nomogram.<p /><p>Language: ja</p>",
language="ja",
issn="0914-3777",
doi="",
url="http://dx.doi.org/"
}