@article{ref1,
title="Isotretinoin and the controversy of psychiatric adverse effects",
journal="International journal of dermatology",
year="2006",
author="Strahan, Jamison E. and Raimer, Sharon",
volume="45",
number="7",
pages="789-799",
abstract="Isotretinoin is a synthetic oral retinoid that has great efficacy against severe, recalcitrant, nodulocystic acne. Since its introduction to the market, it has been associated with a variety of adverse psychiatric effects, including depression, psychosis, mood swings, violent behavior, suicide, and suicide attempts. A MEDLINE review was performed to compile all case reports, case series, adverse drug event reportings, and prospective and retrospective studies relating psychiatric adverse events to isotretinoin. In addition, literature linking a biological mechanism for psychiatric adverse events to retinoid signaling pathways was also reviewed. Although a variety of anecdotal and epidemiologic studies are available, the overall lack of concrete scientific data limits any conclusion that can be drawn about a causal relationship between istotretinoin and psychiatric adverse events. Several lines of evidence link retinoid signaling to theorized psychiatric pathogenesis, but are limited in their applicability to adult neurophysiology.<p /><p>Language: en</p>",
language="en",
issn="0011-9059",
doi="10.1111/j.1365-4632.2006.02660.x",
url="http://dx.doi.org/10.1111/j.1365-4632.2006.02660.x"
}