@article{ref1,
title="Neither DMPS nor DMSA is effective in quantitative elimination of elemental mercury after intentional IV injection",
journal="Clinical toxicology (Philadelphia, Pa.)",
year="2006",
author="Eyer, Florian and Felgenhauer, Norbert and Pfab, Rudolf and Drasch, Gustav and Zilker, Thomas",
volume="44",
number="4",
pages="395-397",
abstract="BACKGROUND: Intravenous injection of elemental mercury (Hg) is rare and considered relatively harmless. Treatment recommendations vary and the effectiveness of chelation therapy is controversial. CASE REPORT: A 27-year-old man intravenously injected 1.5 mL of elemental Hg. Within 12 hours he became febrile, tachycardic and dyspneic. Physical examination was unremarkable. X-rays showed scattered radiodense deposits in the lung, heart, intestinal wall, liver and kidney. The serum Hg level on admission was 172 microg/L and peaked on day 6 at 274 microg/L. Cumulative renal elimination during a five day oral treatment period with 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) was 8 mg and 3 mg, respectively. CONCLUSION: Although urinary excretion could be enhanced during chelation therapy, Hg deposits in organs resulted in negligible elimination of mercury compared to the exposed dose.<p /><p>Language: en</p>",
language="en",
issn="1556-3650",
doi="10.1080/15563650600671795",
url="http://dx.doi.org/10.1080/15563650600671795"
}