@article{ref1,
title="Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine",
journal="Organic and biomolecular chemistry",
year="2006",
author="Alexeev, Dmitriy and Baxter, Robert L. and Campopiano, Dominic J. and Kerbarh, Olivier and Sawyer, Lindsay and Tomczyk, Nicholas and Watt, Rory and Webster, Scott P.",
volume="4",
number="7",
pages="1209-1212",
abstract="The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.<p /><p>Language: en</p>",
language="en",
issn="1477-0520",
doi="10.1039/b517922j",
url="http://dx.doi.org/10.1039/b517922j"
}