@article{ref1,
title="Metabolic acidosis in prometryn (triazine herbicide) self-poisoning",
journal="Clinical toxicology (Philadelphia, Pa.)",
year="2008",
author="Brvar, Miran and Okrajsek, Renata and Kosmina, Polona and Staric, Feliks and Kaps, Rafael and Kozelj, Gordana and Bunc, Matjaz",
volume="46",
number="3",
pages="270-273",
abstract="INTRODUCTION: Prometryn is a triazine herbicide, which is one of the most extensively used groups of herbicides. The mechanism of acute triazine herbicide toxicity in humans is not known. We report a first case of acute prometryn poisoning. CASE REPORT: A 62-year-old male ingested 50 g of prometryn and ethanol in a suicide attempt. On arrival two hours after ingestion, he was somnolent and vomited. Seven hours after ingestion laboratory tests showed metabolic acidosis with a calculated anion gap of 47.5 mmol/L and lactate of 23.4 mmol/L. Gas chromatography/mass spectrometry revealed serum prometryn concentrations of 48.1 mg/L. Hemodialysis corrected metabolic acidosis, but the serum prometryn concentration increased to 67.7 mg/L. The lactate level after hemodialysis was 11.7 mmol/L and returned within normal limits 47 hours after ingestion. The patient was discharged without any sequelae after psychiatric evaluation. CONCLUSION: In high anion gap metabolic acidosis we should consider poisoning with prometryn and other triazine herbicides. Hemodialysis corrects metabolic derangements, but it does not lower serum prometryn concentration.<p /><p>Language: en</p>",
language="en",
issn="1556-3650",
doi="10.1080/15563650701665126",
url="http://dx.doi.org/10.1080/15563650701665126"
}