@article{ref1,
title="Activation of suicidal ideation with adjunctive rufinamide in bipolar disorder",
journal="Epilepsy and behavior",
year="2011",
author="Kaufman, Kenneth R. and Struck, Peter J.",
volume="20",
number="2",
pages="386-389",
abstract="Antiepileptic drugs are effective psychotropics, especially for bipolar disorder, which leads to their use off-label in treatment-refractory cases. A recent publication suggests that rufinamide may be beneficial adjunctively for bipolar disorder with comorbid psychopathology. This report addresses two negative cases with significant psychiatric adverse effects: increased depression, agitation, and activation of suicidal ideation. These findings suggest that adjunctive rufinamide may lead to increased suicidal ideation in patients with treatment-refractory bipolar disorder. Secondary to the course of severe bipolar disorder, rufinamide cannot be specifically implicated; however, clinicians should be aware of this potential significant adverse effect and monitor high-risk patients. Further studies are required to address rufinamide treatment efficacy and severity of adverse effects in patients with bipolar disorder.<p /><p>Language: en</p>",
language="en",
issn="1525-5050",
doi="10.1016/j.yebeh.2010.11.014",
url="http://dx.doi.org/10.1016/j.yebeh.2010.11.014"
}