@article{ref1,
title="Methadone-induced toxic leukoencephalopathy: diagnosis and follow-up by magnetic resonance imaging including diffusion-weighted imaging and apparent diffusion coefficient maps",
journal="Journal of neuroimaging",
year="2011",
author="Cerase, Alfonso and Leonini, Sara and Bellini, Matteo and Chianese, Giuseppe and Venturi, Carlo",
volume="21",
number="3",
pages="283-286",
abstract="BACKGROUND AND PURPOSE: Effects of methadone misuse have been rarely described. The purpose of this case report is to increase the knowledge of methadone-related leukoencephalopathy. METHODS: We report the long-term follow-up by brain magnetic resonance imaging including isotropic diffusion-weighted imaging and mean apparent diffusion coefficient values of a 49-year-old patient who attempted suicide by intravenous methadone. RESULTS AND CONCLUSIONS: Lesion pattern included subtle cerebellar involvement, mainly reversible extensive bilateral and symmetric brain involvement, cystic degeneration in the periventricular regions, sparing of corpus callosum and subcortical U-fibers, development of diffuse brain atrophy, and clear-cut clinical improvement.<p /><p>Language: en</p>",
language="en",
issn="1051-2284",
doi="10.1111/j.1552-6569.2010.00530.x",
url="http://dx.doi.org/10.1111/j.1552-6569.2010.00530.x"
}