@article{ref1,
title="Prolonged delirium after quetiapine overdose",
journal="Pediatric emergency care",
year="2010",
author="Rhyee, Sean Hyun and Pedapati, Ernest Vijay and Thompson, Jennifer",
volume="26",
number="10",
pages="754-756",
abstract="Quetiapine is an atypical antipsychotic agent increasingly used to treat schizophrenia and bipolar disorder in pediatric patients. Few published data exist concerning quetiapine's effects in therapeutic settings or short-term overdose in pediatric and adolescent populations. In this report, we describe a 15-year-old adolescent girl who experienced continued delirium 5 days after an overdose of quetiapine, trazodone, and clonidine. The patient initially presented with sedation and stable vital signs. After 3 days of gradual improvement, she experienced episodes of delirium coinciding with an increase in resting heart rate. On the basis of suspicion for quetiapine-associated antimuscarinic effects, the patient was administered intravenously with physostigmine on the fifth day after ingestion. Treatment resulted in a brief resolution of symptoms. Serum quetiapine levels measured 1 day and 5 days after ingestion were 3400 and 4800 ng/mL, respectively. The use of physostigmine and interpretation of serum levels are discussed further.<p /><p>Language: en</p>",
language="en",
issn="0749-5161",
doi="10.1097/PEC.0b013e3181f39d5b",
url="http://dx.doi.org/10.1097/PEC.0b013e3181f39d5b"
}