@article{ref1,
title="[Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine]",
journal="Annales Francaises d'Anesthesie et de Reanimation",
year="2011",
author="Alluin, A. and Jezequel, J. and Gauthier, N. and Desmaretz, J.-l. and Canevet, C.",
volume="30",
number="10",
pages="752-754",
abstract="We present the case of a 24-year-old-female patient, who made an attempt to autolysis with valproic acid, benzodiazepines and neuroleptic. The valproic acid plasma level was very high (1437 μg/mL), confirming it was a severe intoxication. She presents an acute encephalopathy with prolonged status epilepticus, a lactic metabolic acidosis and hematologic disorders such as bicytopenia. Treatment including L-carnintine and continuous veno-venous haemodialysis (CVVHD) was rapidly introduced to prevent the occurrence of cerebral oedema. The evolution was favourable despite the occurrence of a nosocomial ventilation acute lung injury. The patient had motor sequelae of cranial nerves following status epilepticus extended, which disappeared spontaneously after several days.<p /><p>Language: fr</p>",
language="fr",
issn="0750-7658",
doi="10.1016/j.annfar.2011.05.019",
url="http://dx.doi.org/10.1016/j.annfar.2011.05.019"
}