@article{ref1,
title="Changes in cognitive-emotional and physiological symptoms of depression following STN-DBS for the treatment of Parkinson's disease",
journal="European journal of neurology",
year="2012",
author="Strutt, A. M. and Simpson, R. and Jankovic, J. and York, M. K.",
volume="19",
number="1",
pages="121-127",
abstract="BACKGROUND AND PURPOSE: Subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to have beneficial effects on the motor features of Parkinson's disease (PD), but its impact on non-motor symptoms, most notably mood, has not been fully explored. METHODS: In the first study to independently compare the emotional-cognitive and somatic/physiological symptoms of depression, we examined mood differences in 17 bilateral STN-DBS and 22 matched non-surgical PD patients at baseline and 6 months. RESULTS: The STN-DBS group reported higher levels of depression at baseline with significant endorsement of physical symptomatology. Postoperatively, no significant between-group differences in physical symptoms of depression were found. In contrast, a significant group by time interaction for cognitive-emotional symptoms of depression was found, with the STN-DBS group reporting an increase in psychological symptoms of distress. The STN-DBS group also reported an increase in anxiety following surgery. The suicide rate of 5% found in our study is consistent with other postoperative studies in PD. The impact of changes in levodopa and psychotropic medication are also explored. CONCLUSIONS: Preliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN-DBS may be partially offset by an increase in affective-cognitive symptoms of depression.<p /><p>Language: en</p>",
language="en",
issn="1351-5101",
doi="10.1111/j.1468-1331.2011.03447.x",
url="http://dx.doi.org/10.1111/j.1468-1331.2011.03447.x"
}