@article{ref1,
title="Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol",
journal="World journal of biological psychiatry",
year="2012",
author="Riedel, Michael and Mayr, Andreas and Seemüller, Florian and Maier, Wolfgang and Klingberg, Stefan and Heuser, Isabella and Klosterkötter, Joachim and Gastpar, Markus and Schmitt, Andrea and Sauer, Heinrich and Schneider, Frank and Gaebel, Wolfgang and Jäger, Markus and Moller, Hans-Jurgen and Schennach-Wolff, Rebecca",
volume="13",
number="1",
pages="30-38",
abstract="OBJECTIVE: To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol. METHOD: A total of 274 patients were analysed within a double-blind randomized controlled trial and treated with risperidone or haloperidol. The patients were grouped according to their baseline HAMD-21 total score in a &quot;depressed&quot; (HAMD-21 ≥16) or &quot;non-depressed&quot; (HAMD-21 <16) patient subgroup. PANSS, HAMD-21, GAF, SOFAS and AIMS ratings were performed. Early response was defined as an initial 20% reduction of the PANSS total score from admission to week 2, response as an at least 50% reduction of the PANSS total score from admission to discharge and remission according to the consensus criteria. RESULTS: A total of 124 patients were classified as depressive at baseline with 22 patients still being depressive at discharge. The depressed and non-depressed patients did not significantly differ regarding the treatment with risperidone and haloperidol (P = 0.2270). The depressive patients suffered from significantly more suicidal tendencies (P = 0.0165), had significantly less insight into their illness (P = 0.0152) and featured significantly worse functioning (P = 0.0066). Patients with depressive symptoms achieved remission significantly less often than non-depressed patients. CONCLUSION: The importance of a specific and adequate treatment of depressive symptoms is highlighted.<p /><p>Language: en</p>",
language="en",
issn="1562-2975",
doi="10.3109/15622975.2011.552633",
url="http://dx.doi.org/10.3109/15622975.2011.552633"
}