@article{ref1,
title="Suicide inactivation of tyrosinase in its action on tetrahydropterines",
journal="Journal of enzyme inhibition and medicinal chemistry",
year="2011",
author="Munoz-Munoz, Jose Luis and García-Molina, Francisco and Arribas, Enrique and García-Ruiz, Pedro Antonio and Tudela, José and García-Cánovas, Francisco and Rodriguez-Lopez, Jose Neptuno",
volume="26",
number="5",
pages="728-733",
abstract="Tetrahydrobiopterin (BH(4)), methyl-tetrahydropterin (MBH(4)) and dimethyl-tetrahydropterin (DMBH(4)) are oxidized by tyrosinase in a process during which the suicide inactivation of tyrosinase may occur. From the kinetic study of this process, [Formula: see text] (apparent maximum constant for the suicide inactivation), [Formula: see text] (Michaelis constant for the substrate) and r (number of turnovers that the enzyme makes before the inactivation) can be obtained. From the results obtained, it can be deduced that the velocity of the inactivation governed by ([Formula: see text]) and the potency of the same ([Formula: see text]) follow the order: BH(4) > MBH(4) > DMBH(4).<p /><p>Language: en</p>",
language="en",
issn="1475-6366",
doi="10.3109/14756366.2010.548811",
url="http://dx.doi.org/10.3109/14756366.2010.548811"
}