@article{ref1,
title="Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury",
journal="CNS spectrums",
year="2020",
author="Pardini, Matteo and Grafman, Jordan and Raymont, Vanessa and Amore, Mario and Serafini, Gianluca and Koenigs, Michael and Krueger, Frank",
volume="25",
number="1",
pages="24-31",
abstract="OBJECTIVES: The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI). METHODS: Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory. RESULTS: Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation. CONCLUSIONS: The left rlPFC plays a crucial role in SI independently of depression and global functioning.<p /><p>Language: en</p>",
language="en",
issn="1092-8529",
doi="10.1017/S1092852918001694",
url="http://dx.doi.org/10.1017/S1092852918001694"
}