@article{ref1,
title="Serial measurement of glyphosate blood concentration in a glyphosate potassium herbicide-intoxicated patient: A case report",
journal="American journal of emergency medicine",
year="2019",
author="Cho, Yongchul and Jeong, Wonjoon and Kim, Suncheun and Choi, Hyunsoo and You, Yeonho and Cho, Sunguk and Oh, Sekwang and Ahn, Hongjoon and Park, Jungsoo and Min, Jinhong",
volume="37",
number="8",
pages="1600.e5-1600.e6",
abstract="INTRODUCTION: This report describes changes in blood and urine concentrations of glyphosate potassium over time and their correlations with clinical symptoms in a patient with acute glyphosate potassium poisoning. CASE REPORT: A 67-year-old man visited the emergency center after ingesting 250 mL of a glyphosate potassium-based herbicide 5 h before. He was alert but presented with nausea, vomiting, and bradyarrhythmia with atrial fibrillation (tall T waves). Laboratory findings revealed a serum potassium level of 6.52 mEq/L. After treatment with an injection of calcium gluconate, insulin with glucose, bicarbonate, and an enema with polystyrene sulfonate, the patient's serum potassium level normalized and the bradyarrhythmia converted to a normal sinus rhythm. During admission, the blood and urine concentration of glyphosate and urine aminomethylphosphonic acid (AMPA, a glyphosate metabolite) was measured at regular time intervals. The patient's glyphosate blood concentration on admission was 11.48 mg/L, and it had decreased rapidly by 16 h and maintained about 1mgl/L by 70 h after admission. Urine glyphosate and AMPA levels had also decreased rapidly by 6 h after admission. DISCUSSION: Glyphosate potassium poisoning causes hyperkalemia. Blood concentrations of glyphosate were decreased rapidly by 16 h after admission, and urine concentrations were also decreased by 6 h after admission.<p /><p>Language: en</p>",
language="en",
issn="0735-6757",
doi="10.1016/j.ajem.2019.04.042",
url="http://dx.doi.org/10.1016/j.ajem.2019.04.042"
}