@article{ref1,
title="Epidemiological and clinical variables related with the predominant polarity on bipolar disorder: A systematic review",
journal="Revista de psiquiatría y salud mental (English edition)",
year="2019",
author="García-Jiménez, Jesús and Álvarez-Fernández, Marisol and Aguado-Bailón, Lidia and Gutiérrez-Rojas, Luis",
volume="12",
number="1",
pages="52-62",
abstract="INTRODUCTION: Current classification of bipolar disorder (BD) in type i or type ii, however useful, may be insufficient to provide relevant clinical information in some patients. As a result, complementary classifications are being proposed, like the predominant polarity (PP) based, which is defined as a clear tendency in the patient to present relapses in the manic or depressive poles. METHODS: We carried out a search in PubMed and Web of Science databases, following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses -PRISMA- guidelines, to identify studies about BD reporting PP. The search is updated to June 2016. RESULTS: Initial search revealed 907 articles, of which 16 met inclusion criteria. Manic PP was found to be associated with manic onset, drug consumption prior to onset and a better response to atypical antipsychotics and mood stabilisers. Depressive PP showed an association with depressive onset, more relapses, prolonged acute episodes, a greater suicide risk and a later diagnosis of BD. Depressive PP was also associated with anxiety disorders, mixed symptoms, melancholic symptoms and a wider use of quetiapine and lamotrigine. LIMITATIONS: Few prospective studies. Variability in some results. CONCLUSION: PP may be useful as a supplement to current BD classifications. We have found consistent data on a great number of studies, but there is also contradictory information regarding PP. Further studies are needed, ideally of a prospective design and with a unified methodology.<p /><p>Language: en</p>",
language="en",
issn="2173-5050",
doi="10.1016/j.rpsm.2017.06.008",
url="http://dx.doi.org/10.1016/j.rpsm.2017.06.008"
}