@article{ref1,
title="Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy",
journal="Basic and Clinical Pharmacology and Toxicology",
year="2017",
author="Ge, Yongchun and Xu, Bin and Zhu, Shuhua and Li, Chuan and He, Qunpeng and Zhu, Tingting and Fan, Rong and Gong, Dehua",
volume="121",
number="4",
pages="368-370",
abstract="Valproic acid (VPA) is widely used for the treatment of epilepsy. However, its overdose can cause intoxication and could be life-threatening. Due to the lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of VPA which was successfully treated with liver support therapy. A previously healthy woman was admitted due to coma and hypotension after intentional ingestion of 20 g of sodium valproate. Her serum concentration of VPA measured on admission was 420.84 mg/L. In addition to standard therapy, she received two sessions of extracorporeal blood purification using a system based on fractionated plasma separation and adsorption mode integrated with continuous veno-venous haemofiltration (FPSA-CVVH), which is usually used for liver support therapy at our hospital. Her serum concentration of VPA decreased dramatically to 40.18 mg/L and her consciousness recovered completely within 24 hr after admission. Therefore, although haemodialysis has been reported to be effective in the treatment for VPA poisoning, FPSA-CVVH may provide an option for patients who require bedside therapy but have an unstable haemodynamic status or other conditions that result in inability to endure haemodialysis.<p /><p>Language: en</p>",
language="en",
issn="1742-7835",
doi="10.1111/bcpt.12807",
url="http://dx.doi.org/10.1111/bcpt.12807"
}