@article{ref1,
title="Lethality associated with snake venom exposure can be predicted by temperature drop in Swiss mice",
journal="Toxicon: Journal of the International Society on Toxinology",
year="2024",
author="De Jesus, Rosa and Britton, Gabrielle B. and Herrera, Lizzi and Madrid, Alanna and Lleonart, Ricardo and Fernández, Patricia L.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Establishing humane endpoints to minimize animal suffering in studies on snake venom toxicity and antivenom potency tests is crucial. Our findings reveal that Swiss mice exhibit early temperature drop following exposure to different snake venoms and combinations of venoms and antivenoms, predicting later mortality. Evaluating temperature we can identify within 3 hours post-inoculation, the animals that will not survive in a period of 48 hours. Implementing temperature as a criterion would significantly reduce animal suffering in these studies without compromising the outcomes.<p /> <p>Language: en</p>",
language="en",
issn="0041-0101",
doi="10.1016/j.toxicon.2024.107831",
url="http://dx.doi.org/10.1016/j.toxicon.2024.107831"
}