@article{ref1,
title="Seizure-related falls and near falls in LGI1-IgG autoimmune encephalitis",
journal="Neurology. Clinical practice",
year="2024",
author="Li, Xiaoyang and Gupta, Pranjal and Smith, Kelsey M. and Madhavan, Ajay and Rezk, Mohamed and Zekeridou, Anastasia and Flanagan, Eoin P. and McKeon, Andrew and Pittock, Sean J. and Britton, Jeffrey W. and Dubey, Divyanshu",
volume="14",
number="3",
pages="e200301-e200301",
abstract="OBJECTIVES: To study the frequency, causes, and consequences of seizure-related falls and near falls in LGI1-IgG autoimmune encephalitis. <br><br>METHODS: We retrospectively reviewed 136 patients seen at Mayo Clinic with (1) LGI1-IgG seropositivity, (2) clinical phenotypes compatible with LGI1-IgG autoimmune encephalitis, and (3) falls or near falls related to seizures. The clinical documentation, MRI, and EEG data were collected and reviewed. <br><br>RESULTS: In this cohort of 136 patients, 27% (n = 36) had falls or near falls related to seizures. The median age was 67 years (range 49-86 years) and 23/36 (64%) were male. Facio-brachio-crural dystonic seizures (21/36, 58%) and drop attacks (9/36, 25%) were the most common causes. Seizure-related falls resulted in injuries in 18/30 (60%), ranging from skin lacerations, joint dislocations, bone fractures to life-threatening intracranial hemorrhage. The injuries occurred most with drop attacks 8/9 (89%). Seizure-related falls or near falls resolved with immunotherapy in 24/32 (75%) whereas the responsiveness to anti-seizure medication alone was poor (4/32, 13%). <br><br>DISCUSSION: Our study demonstrates that seizure-related falls and near falls are common in LGI1-IgG autoimmune encephalitis. Early diagnosis, prompt immunotherapy initiation, and proper counseling are key to improving functional outcomes and preventing secondary injuries.<p /> <p>Language: en</p>",
language="en",
issn="2163-0402",
doi="10.1212/CPJ.0000000000200301",
url="http://dx.doi.org/10.1212/CPJ.0000000000200301"
}