@article{ref1,
title="The Toronto Adolescent and Youth Cohort Study: study design and early data related to psychosis spectrum symptoms, functioning, and suicidality",
journal="Biological psychiatry: cognitive neuroscience and neuroimaging",
year="2024",
author="Cleverley, Kristin and Foussias, George and Ameis, Stephanie H. and Courtney, Darren B. and Goldstein, Benjamin I. and Hawke, Lisa D. and Kozloff, Nicole and Quilty, Lena C. and Rotenberg, Martin and Wheeler, Anne L. and Andrade, Brendan F. and Aitken, Madison and Mahleka, Don and Jani, Melanie and Frayne, Margot and Wong, Jimmy K. Y. and Kelly, Rachel and Dickie, Erin W. and Felsky, Daniel and Haltigan, John D. and Lai, Meng-Chuan and Nikolova, Yuliya S. and Tempelaar, Wanda and Wang, Wei and Battaglia, Marco and Husain, Muhammad Omair and Kidd, Sean and Kurdyak, Paul and Levitan, Robert D. and Lewis, Stephen P. and Polillo, Alexia and Szatmari, Peter and van der Miesen, Anna I. R. and Ahmadzadasl, Masoud and Voineskos, Aristotle N. and TAY Cohort Study Team, ",
volume="9",
number="3",
pages="253-264",
abstract="BACKGROUND: Psychosis spectrum symptoms (PSSs) occur in a sizable percentage of youth and are associated with poorer cognitive performance, poorer functioning, and suicidality (i.e., suicidal thoughts and behaviors). PSSs may occur more frequently in youths already experiencing another mental illness, but the antecedents are not well known. The Toronto Adolescent and Youth (TAY) Cohort Study aims to characterize developmental trajectories in youths with mental illness and understand associations with PSSs, functioning, and suicidality.   METHODS: The TAY Cohort Study is a longitudinal cohort study that aims to assess 1500 youths (age 11-24 years) presenting to tertiary care. In this article, we describe the extensive diagnostic and clinical characterization of psychopathology, substance use, functioning, suicidality, and health service utilization in these youths, with follow-up every 6 months over 5 years, including early baseline data.   RESULTS: A total of 417 participants were enrolled between May 4, 2021, and February 2, 2023. Participants met diagnostic criteria for an average of 3.5 psychiatric diagnoses, most frequently anxiety and depressive disorders. Forty-nine percent of participants met a pre-established threshold for PSSs and exhibited higher rates of functional impairment, internalizing and externalizing symptoms, and suicidality than participants without PSSs.   CONCLUSIONS: Initial findings from the TAY Cohort Study demonstrate the feasibility of extensive clinical phenotyping in youths who are seeking help for mental health problems. PSS prevalence is much higher than in community-based studies. Our early data support the critical need to better understand longitudinal trajectories of clinical youth cohorts in relation to psychosis risk, functioning, and suicidality.<p /> <p>Language: en</p>",
language="en",
issn="2451-9030",
doi="10.1016/j.bpsc.2023.10.011",
url="http://dx.doi.org/10.1016/j.bpsc.2023.10.011"
}