@article{ref1,
title="Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters",
journal="Psychiatry research",
year="2008",
author="Bah, Jessica and Lindstrom, Martin and Westberg, Lars and Mannerås, Louise and Ryding, Erik and Henningsson, Susanne and Melke, Jonas and Rosén, I. and Träskman-Bendz, Lil and Eriksson, E.",
volume="162",
number="3",
pages="221-229",
abstract="The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using (123)I-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n= 9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.  <p></p>  <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.pscychresns.2007.07.004",
url="http://dx.doi.org/10.1016/j.pscychresns.2007.07.004"
}