@article{ref1,
title="A proton magnetic spectroscopy research on hippocampus metabolisms in people with suicide-attempted depressions",
journal="Sichuan Da Xue Xue Bao Yi Xue Ban",
year="2009",
author="Li, Jiang and Kuang, Wei-Hong and Zou, Ke and Deng, Wenbin and Li, Tianhong and Gong, Qi-Yong and Sun, Xue-Li",
volume="40",
number="1",
pages="59-62",
abstract="OBJECTIVE: To investigate the metabolic features of hippocampus in people with suicide-attempted depressions. METHODS: Proton resonance spectroscopy (1H-MRS) was performed on the bilateral hippocampi of 24 patients with suicide-attempted depressions and 24 healthy people. The ratios of N-acetylasparte(NAA)/creatine (Cr), choline(Cho)/Cr and myoinositol(mI)/Cr were calculated and used as markers reflecting the metabolic levels of NAA, Cho and mI. The differences between the patients with suicide-attempted depressions and the healthy people were analyzed. The left hippocampus was also compared with the right to determine the asymmetry of the hippocampus metabolic. RESULTS: The ratio of NAA/Cr in the left hippocampus of the patients with suicide-attempted depressions was significantly less than that of the healthy control (P < 0.05). The ratio of NAA/Cr in the left hippocampus was significantly greater than in the right hippocampus of the healthy control (P < 0.05). However, the left-right deference of the ratio of NAA/Cr disappeared in the patients with suicide-attempted depressions. There was an asymmetry between the left and right hippocampi in the healthy people (P < 0.05), but not in the patients with suicide-attempted depressions (P > 0.05). No correlations between the metabolic markers and the course of disease, number of episodes and HAMD17 scores were found in the patients with suicide-attempted depressions (P > 0.05). CONCLUSION: There is a decrease of metabolite in the left hippocampus of patients with suicide-attempted depressions. The asymmetry of the bilateral hippocampi disappears in the patients with suicide-attempted depressions.<p /> <p>Language: zh</p>",
language="zh",
issn="1672-173X",
doi="",
url="http://dx.doi.org/"
}