%0 Journal Article
%T Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma
%J Psychosomatic medicine
%D 2008
%A Scott, Kate M.
%A Von Korff, M.
%A Alonso, Jordi
%A Angermeyer, Matthias C.
%A Benjet, Corina
%A Bruffaerts, Ronny
%A de Girolamo, Giovanni
%A Haro, Josep Maria
%A Kessler, Ronald C.
%A Kovess, Viviane
%A Ono, Y.
%A Ormel, Johan
%A Posada-Villa, Jose
%V 70
%N 9
%P 1035-1043
%X OBJECTIVES: To investigate a) whether childhood adversity predicts adult-onset asthma; b) whether early-onset depressive/anxiety disorders predict adult-onset asthma; and c) whether childhood adversity and early-onset depressive/anxiety disorders predict adult-onset asthma independently of each other. Previous research has suggested, but not established, that childhood adversity may predict adult-onset asthma and, moreover, that the association between mental disorders and asthma may be a function of shared risk factors, such as childhood adversity. METHODS: Ten cross-sectional population surveys of household-residing adults (>18 years, n = 18,303) assessed mental disorders with the Composite International Diagnostic Interview (CIDI 3.0) as part of the World Mental Health surveys. Assessment of a range of childhood family adversities was included. Asthma was ascertained by self-report of lifetime diagnosis and age of diagnosis. Survival analyses calculated hazard ratios (HRs) for risk of adult-onset (>age 20 years) asthma as a function of number and type of childhood adversities and early-onset (<age 21 years) depressive and anxiety disorders, adjusting for current age, sex, country, education, and current smoking. RESULTS: Childhood adversities predicted adult-onset asthma with risk increasing with the number of adversities experienced (HRs = 1.49-1.71). Early-onset depressive and anxiety disorders also predicted adult-onset asthma (HRs = 1.67-2.11). Childhood adversities and early-onset depressive and anxiety disorders both predicted adult-onset asthma after mutual adjustment (HRs = 1.43-1.91). CONCLUSIONS: Childhood adversities and early-onset depressive/anxiety disorders independently predict adult-onset asthma, suggesting that the mental disorder-asthma relationship is not a function of a shared background of childhood adversity.<p /> <p>Language: en</p>
%G en
%I Lippincott Williams and Wilkins
%@ 0033-3174
%U http://dx.doi.org/10.1097/PSY.0b013e318187a2fb