%0 Journal Article
%T Role of IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 genes polymorphisms in suicidal behavior
%J Archives of suicide research
%D 2009
%A Omrani, Mir Davood
%A Bushehri, Behzad
%A Bagheri, Morteza
%A Salari-Lak, Shaker
%A Alipour, Azize
%A Anoshae, Mohamad-Reza
%A Massomi, Reza
%V 13
%N 4
%P 330-339
%X In this study, it was determined whether the IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms were associated with suicidal behavior. One hundred forty five patients with suicidal behavior and 160 normal individuals were genotyped for IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms using ASO-PCR method. TNF-alpha -308 G/G genotype has been increased in males with completed suicide behavior versus control group (p value = 0.017). IL-10 -1082 A/A genotype is higher in both male and female suicide completed groups (p value = 0.017). IFN-gamma (+874) A/A genotype was significantly higher in males with completed suicide behavior versus normal male control (p value = 0.027). It can be concluded that IL-10, IFN-gamma, and TNF-alpha polymorphisms may play a role in suicidal behavior.<p /> <p>Language: en</p>
%G en
%I Informa - Taylor and Francis Group
%@ 1381-1118
%U http://dx.doi.org/10.1080/13811110903266418