%0 Journal Article
%T The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers
%J Human psychopharmacology
%D 2010
%A Takahashi, Masahiro
%A Iwamoto, Kunihiro
%A Kawamura, Y.
%A Nakamura, Yukako
%A Ishihara, Ryoko
%A Uchiyama, Yuji
%A Ebe, Kazutoshi
%A Noda, Akiko
%A Noda, Y.
%A Yoshida, Kentaro
%A Iidaka, Tetsuya
%A Ozaki, Norio
%V 25
%N 3
%P 260-267
%X OBJECTIVE: To assess the effects of two anxiolytics, diazepam and tandospirone, on driving performance from methodological viewpoints taking frequent rear-end collisions into account. METHODS: In this double-blinded, three-way crossover trial, 18 healthy males received acute doses of 20 mg tandospirone (TSP), 5 mg diazepam (DZP), and placebo (PCB). The subjects were administered three driving tasks-road tracking, car following, and harsh braking-performed using a driving simulator and three cognitive tasks-Wisconsin Card Sorting Test, Continuous Performance Test, and N-back test-at baseline and at 1 and 4 h post-dosing. The Stanford Sleepiness Scale scores were also assessed. RESULTS: DZP nonsignificantly increased the percent change of brake reaction time (BRT) as compared to PCB at 4 h post-dosing. TSP nonsignificantly decreased the percent change of BRT as compared to PCB. Consequently, there was a significant difference in the percent change of BRT between DZP and TSP at 4 h post-dosing. For the remaining tasks, no statistically significant effects of treatment were observed. CONCLUSIONS: Acute doses of DZP significantly impaired the harsh-braking performance as compared to acute doses of TSP. These findings suggest that TSP may be used more safely in patients' driving activities.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 0885-6222
%U http://dx.doi.org/10.1002/hup.1105