%0 Journal Article
%T Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder
%J British journal of psychiatry
%D 2007
%A Flory, Janine D.
%A Newcorn, Jeffrey H.
%A Miller, Carlin
%A Harty, Seth
%A Halperin, Jeffrey M.
%V 190
%N 
%P 410-414
%X BACKGROUND: Impulsive aggression in adulthood is associated with disturbances in serotonergic function. In contrast, research examining this association in childhood has yielded inconsistent results. AIMS: The current study examined the prospective relationship between serotonergic function measured in childhood and the later emergence of antisocial personality disorder. METHOD: Hormonal response to fenfluramine, an index of serotonergic function, was assessed in 58 children with attention-deficit hyperactivity disorder between 1990 and 1997 when they were aged 7-11 years. Approximately 9 years later these individuals were evaluated for antisocial personality disorder. RESULTS: Lower serotonergic responsivity assessed in childhood predicted the development of antisocial personality disorder (t (56)=2.25, P=0.028). CONCLUSIONS: These results provide a critical link between the child and adult literature on the covariation of impulsive aggression and serotonergic function and suggest a potential explanation for inconsistencies in the childhood literature.<p /><p>Language: en</p>
%G en
%I Royal College of Psychiatry
%@ 0007-1250
%U http://dx.doi.org/10.1192/bjp.bp.106.027847