%0 Journal Article
%T Synthesis and properties of the derivatives of 2-alkylthio-4-oxo-3,4- (and -1,4)-dihydropyrido-[2,3-d]pyrimidine-5- and -6-carboxylic acids
%J Farmaco (Società chimica italiana : 1989)
%D 1990
%A Sladowska, H.
%A Bartoszko-Malik, A.
%A Zawisza, T.
%V 45
%N 1
%P 111-121
%X Condensation of diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (I) with the corresponding isothiocyanates afforded derivatives of ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine-5-carboxylate (V-VII). Alkylation of (V), (VI) and (XI) gave the corresponding derivatives of ethyl 2-alkylthio-4-oxo-3,4-(and 1,4)-dihydropyrido[2,3-d]pyrimidine-5- and -6- carboxylate [(XII-XVI), (XX-XXII)]. Some of the obtained compounds were active pharmacologically.<p /><p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0014-827X
%U http://dx.doi.org/