%0 Journal Article
%T Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations
%J Psychopharmacology
%D 1984
%A Pomara, N.
%A Stanley, B.
%A Block, R.
%A Guido, J.
%A Russ, D.
%A Berchou, R.
%A Stanley, M.
%A Greenblatt, D. J.
%A Newton, R. E.
%A Gershon, S.
%V 84
%N 3
%P 342-346
%X Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administration. Significant impairments were found in response to all doses of diazepam. The maximum impairment occurred at 1 h, which coincided with the highest plasma concentration of the drug.<p /><p>Language: en</p>
%G en
%I Holtzbrinck Springer Nature Publishing Group
%@ 0033-3158
%U http://dx.doi.org/