%0 Journal Article
%T Self-referential thinking, suicide, and function of the cortical midline structures and striatum in mood disorders: Possible implications for treatment studies of mindfulness-based interventions for bipolar depression
%J Depression research and treatment
%D 2012
%A Marchand, William R.
%V 2012
%N online
%P 246725-246725
%X Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, and studies of these approaches for bipolar disorder are warranted. The aim of this paper is to provide a conceptual background for such studies by reviewing key findings from diverse lines of investigation. Results of that review indicate that cortical midline structures (CMS) appear to link abnormal self-referential thinking to emotional dysregulation in mood disorders. Furthermore, CMS and striatal dysfunction may play a role in the neuropathology underlying suicide-related thoughts and behaviors. Thus, combining studies of mindfulness interventions targeting abnormal self-referential thinking with functional imaging of CMS and striatal function may help delineate the neurobiological mechanisms of action of these treatments.<p /> <p>Language: en</p>
%G en
%I Hindawi Publishing
%@ 2090-1321
%U http://dx.doi.org/10.1155/2012/246725