%0 Journal Article
%T Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports
%J Forensic science international
%D 2000
%A Marques, Estela P.
%A Gil, F.
%A Proen'ca, P.
%A Monsanto, P.
%A Oliveira, M. F.
%A Castanheira, A.
%A Vieira, D. N.
%V 110
%N 2
%P 145-152
%X This paper describes an analytical method for strychnine determination in biological samples by gas chromatography/mass spectrometry and their application in the investigation of two cases involving strychnine ingestion: A fatal case and a clinical one. The strychnine is isolated from biological samples using a liquid-liquid extraction procedure. The clean-up procedure is performed using an acid solution. Papaverine is used as internal standard in the quantification of strychnine. In the analysed specimens, the limits of quantification were 0.1 microg/ml or 0.1 microg/g. The recovery rate ranged from 75.0% to 98.7% and the coefficients of variation ranged from 4.8% to 10.5%.<p /><p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0379-0738
%U http://dx.doi.org/