%0 Journal Article
%T Severe injury triggers antigen-specific T-helper cell dysfunction
%J Shock
%D 1999
%A Kelly, J. L.
%A O'Suilleabhain, C. B.
%A Soberg, C. C.
%A Mannick, J. A.
%A Lederer, J. A.
%V 12
%N 1
%P 39-45
%X Although it is established that post-injury immune dysfunction involves alterations in T-cell function, the effects of injury on T-cell function in vivo are poorly understood. This study uses a mouse injury model and an antigen immunization approach to investigate the influence of injury on antigen-specific T-helper cell function. We report here that injury triggered a significant reduction in antigen-specific T-helper-1 (Th1)-dependent IgG2a antibody formation, while IgM, IgG1, and IgE production was unchanged. In addition, injury caused a reduction in cytokine production (IL-2, IFNgamma and IL-10) by antigen-stimulated T-cells. We also demonstrate that interleukin 12 (IL-12), a cytokine that promotes Th1 cell differentiation, restored IgG2a antibody formation and corrected the injury-induced reduction in antigen-stimulated cytokine production. Taken together, these findings indicate that severe injury induces a dramatic reduction in Th1 cell function in vivo and suggest that therapies designed to restore Th1 cell function may be beneficial to the injured host.<p /><p>Language: en</p>
%G en
%I Lippincott Williams and Wilkins
%@ 1073-2322
%U http://dx.doi.org/