%0 Journal Article
%T MDMA use and neurocognition: a meta-analytic review
%J Psychopharmacology
%D 2007
%A Kalechstein, Ari D.
%A De La Garza, Richard
%A Mahoney, James J.
%A Fantegrossi, William E.
%A Newton, Thomas F.
%V 189
%N 4
%P 531-537
%X RATIONALE: To determine the association between MDMA misuse and neurocognition using meta-analysis. OBJECTIVE: Separate analyses were conducted based on two sets of inclusion/exclusion criteria. A relatively stringent set required that the subjects be matched on important moderator variables, whereas the other did not. The study participants' performance in the following neurocognitive domains was reviewed: attention/concentration, verbal and nonverbal learning and memory, psychomotor speed and executive systems functioning. RESULTS: In the 11 studies meeting the relatively stringent inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Similarly, in the 23 studies meeting the relatively lenient inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Small to medium effect sizes were generally observed. A comparison of the effect sizes across the two sets of analyses did not reveal significant differences. CONCLUSIONS: The findings from this review reveal that MDMA use is associated with neurocognitive deficits. The implications of these findings are discussed.<p /><p>Language: en</p>
%G en
%I Holtzbrinck Springer Nature Publishing Group
%@ 0033-3158
%U http://dx.doi.org/10.1007/s00213-006-0601-2