%0 Journal Article
%T The effects of aging and oxidative stress on psychomotor and cognitive behavior
%J Age (Omaha)
%D 1999
%A Shukitt-Hale, B.
%V 22
%N 1
%P 9-17
%X Decrements in motor and cognitive function occur in aging, possibly due to oxidative stress-induced damage to the brain. Declines in antioxidant defense mechanisms have been postulated as a causative factor in these age-related decrements, however a clear link between oxidative stress (OS) and behavioral changes in aging has yet to be established. This review shows that age-validated psychomotor and cognitive tests are sensitive to behavioral deficits under different models of OS, including: 1) decreasing OS protection by depleting glutathione and then increasing the OS with dopamine; 2) 100% oxygen exposure; and 3) radiation. Furthermore, interventions that reduce OS result in concurrent improvements in age-associated behavioral deficits. Therefore, age-related changes in behavior may result from an inability to cope with OS that occurs throughout the life-span.<p /><p>Language: en</p>
%G en
%I 
%@ 0161-9152
%U http://dx.doi.org/10.1007/s11357-999-0002-7