%0 Journal Article
%T Neurobiological mechanisms for impulsive-aggression: The role of MAOA
%J Current topics in behavioral neurosciences
%D 2014
%A Dorfman, Hayley M.
%A Meyer-Lindenberg, Andreas
%A Buckholtz, Joshua W.
%V 17
%N 
%P 297-313
%X Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular-impulsive (reactive) aggression-appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.<p /> <p>Language: en</p>
%G en
%I Holtzbrinck Springer Nature Publishing Group
%@ 1866-3370
%U http://dx.doi.org/10.1007/7854_2013_272