%0 Journal Article
%T Adding fuel to the fire: the impact of stress on the ageing brain
%J Trends in neurosciences
%D 2015
%A Prenderville, Jack A.
%A Kennedy, Paul J.
%A Dinan, Timothy G.
%A Cryan, John F.
%V 38
%N 1
%P 13-25
%X Both ageing and chronic stress are associated with altered brain plasticity, dysregulation of the immune system, and an increased risk of developing brain disorders; all of which have consequences for cognitive and emotional processing. Here we examine the similarities between behavioural changes during ageing and stress altered behaviours (anxiety, depressive-like behaviour, cognition, and sociability) in rodents and humans. The molecular mechanisms hypothesised to mediate age-related changes in brain function including dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, dysregulation of neurotransmission and neurotrophic factor signalling, increased inflammatory state, genetic and epigenetic changes, oxidative stress, metabolic changes, and changes in the microbiota-gut-brain axis are discussed. Finally, we explore how the already stressed aged brain psychologically and physiologically responds to external stressors.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0166-2236
%U http://dx.doi.org/