%0 Journal Article
%T Antidepressant use and recurrent falls in community-dwelling older adults: findings from the Health ABC Study
%J Annals of pharmacotherapy
%D 2016
%A Marcum, Zachary A.
%A Perera, Subashan
%A Thorpe, Joshua M.
%A Switzer, Galen E.
%A Castle, Nicholas G.
%A Strotmeyer, Elsa S.
%A Simonsick, Eleanor M.
%A Ayonayon, Hilsa N.
%A Phillips, Caroline L.
%A Rubin, Susan
%A Zucker-Levin, Audrey R.
%A Bauer, Douglas C.
%A Shorr, Ronald I.
%A Kang, Yihuang
%A Gray, Shelly L.
%A Hanlon, Joseph T.
%V 50
%N 7
%P 525-533
%X BACKGROUND: Few studies have compared the risk of recurrent falls across various antidepressant agents-using detailed dosage and duration data-among community-dwelling older adults, including those who have a history of a fall/fracture. <br><br>OBJECTIVE: To examine the association of antidepressant use with recurrent falls, including among those with a history of falls/fractures, in community-dwelling elders. <br><br>METHODS: This was a longitudinal analysis of 2948 participants with data collected via interview at year 1 from the Health, Aging and Body Composition study and followed through year 7 (1997-2004). Any antidepressant medication use was self-reported at years 1, 2, 3, 5, and 6 and further categorized as (1) selective serotonin reuptake inhibitors (SSRIs), (2) tricyclic antidepressants, and (3) others. Dosage and duration were examined. The outcome was recurrent falls (≥2) in the ensuing 12-month period following each medication data collection. <br><br>RESULTS: Using multivariable generalized estimating equations models, we observed a 48% greater likelihood of recurrent falls in antidepressant users compared with nonusers (adjusted odds ratio [AOR] = 1.48; 95% CI = 1.12-1.96). Increased likelihood was also found among those taking SSRIs (AOR = 1.62; 95% CI = 1.15-2.28), with short duration of use (AOR = 1.47; 95% CI = 1.04-2.00), and taking moderate dosages (AOR = 1.59; 95% CI = 1.15-2.18), all compared with no antidepressant use. Stratified analysis revealed an increased likelihood among users with a baseline history of falls/fractures compared with nonusers (AOR = 1.83; 95% CI = 1.28-2.63). <br><br>CONCLUSION: Antidepressant use overall, SSRI use, short duration of use, and moderate dosage were associated with recurrent falls. Those with a history of falls/fractures also had an increased likelihood of recurrent falls.<br><br>© The Author(s) 2016.<p /> <p>Language: en</p>
%G en
%I Harvey Whitney Books
%@ 1060-0280
%U http://dx.doi.org/10.1177/1060028016644466