%0 Journal Article
%T Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults
%J International journal of geriatric psychiatry
%D 2016
%A Johnell, Kristina
%A Jonasdottir Bergman, Gudrun
%A Fastbom, Johan
%A Danielsson, Bengt
%A Borg, Natalia
%A Salmi, Peter
%V 32
%N 4
%P 414-420
%X OBJECTIVE: To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults. <br><br>METHODS: We performed a nationwide matched (age, sex, and case event day) case-control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co-morbidity index, dementia and number of other drugs. <br><br>RESULTS: Antidepressants were the psychotropic most strongly related to fall injuries (ORadjusted : 1.42; 95% CI: 1.38-1.45) and antipsychotics to hospitalizations (ORadjusted : 1.22; 95% CI: 1.19-1.24) and death (ORadjusted : 2.10; 95% CI: 2.02-2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted : 1.53; 95% CI: 1.39-1.68), hospitalization (4 psychotropics vs 0: ORadjusted : 1.27; 95% CI: 1.22-1.33) and death (4 psychotropics vs 0: ORadjusted : 2.50; 95% CI: 2.33-2.69) in a dose-response manner. Among persons with dementia (n = 58,984), a dose-response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted : 1.99; 95% CI: 1.76-2.25). <br><br>CONCLUSIONS: Our findings support a cautious prescribing of multiple psychotropic drugs to older patients.<br><br>Copyright © 2016 John Wiley & Sons, Ltd.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 0885-6230
%U http://dx.doi.org/10.1002/gps.4483