%0 Journal Article
%T Association between diabetes and risk of suicide death: a meta-analysis of 3 million participants
%J Comprehensive psychiatry
%D 2016
%A Wang, Ying
%A Tang, Shiming
%A Xu, Shunsheng
%A Weng, Shenhong
%A Liu, Zhongchun
%V 71
%N 
%P 11-16
%X BACKGROUND: Results of the relationships between diabetes and the risk of suicide death are inconclusive. This meta-analysis was conducted to assess this association. <br><br>METHODS: We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library up to February 29, 2016 for relevant observational studies regarding the association between diabetes and risk of suicide. Random-effects models were used to calculate summary relative risk (RR) and 95% confidence interval (CI). <br><br>RESULTS: 6 observational studies (8 independent reports) with a total of 3,075,214 participants and 3038 suicide deaths events were included in the meta-analysis. Overall, diabetes was not associated with risk of suicide deaths, with significant heterogeneity among studies observed (Summary RR=1.61, 95% CI: 0.91-2.83, Pheterogeneity<0.001, I(2)=97.2%). No publication bias was detected across studies, and both the subgroup analysis and sensitivity analysis suggested that the general result was robust. <br><br>CONCLUSION: Our meta-analysis based on more than 3 million participants indicates that diabetes is not associated with increased risk of suicide death. Further well-designed prospective cohort studies are needed to confirm the findings of this meta-analysis.<br><br>Copyright © 2016 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0010-440X
%U http://dx.doi.org/10.1016/j.comppsych.2016.08.006