%0 Journal Article
%T Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
%J Translational psychiatry
%D 2017
%A Rentería, M. E.
%A Schmaal, L.
%A Hibar, D. P.
%A Couvy-Duchesne, B.
%A Strike, L. T.
%A Mills, N. T.
%A de Zubicaray, G. I.
%A McMahon, K. L.
%A Medland, S. E.
%A Gillespie, N. A.
%A Hatton, S. N.
%A Lagopoulos, J.
%A Veltman, D. J.
%A van der Wee, N.
%A van Erp, T. G. M.
%A Wittfeld, K.
%A Grabe, H. J.
%A Block, A.
%A Hegenscheid, K.
%A Völzke, H.
%A Veer, I. M.
%A Walter, H.
%A Schnell, K.
%A Schramm, E.
%A Normann, C.
%A Schoepf, D.
%A Konrad, C.
%A Zurowski, B.
%A Godlewska, B. R.
%A Cowen, P. J.
%A Penninx, B. W. J. H.
%A Jahanshad, N.
%A Thompson, P. M.
%A Wright, M. J.
%A Martin, N. G.
%A Christensen, H.
%A Hickie, I. B.
%V 7
%N 5
%P e1116-e1116
%X The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N=451) vs healthy controls (N=1996) or MDD patients with no suicidal symptoms (N=650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P=4.12 × 10(-3)) or a 2.87% smaller volume compared with controls (Cohen's d=-0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P=0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments.<p /> <p>Language: en</p>
%G en
%I Nature Publishing Group
%@ 2158-3188
%U http://dx.doi.org/10.1038/tp.2017.84