%0 Journal Article %T Effect of insomnia treatments on depression: a systematic review and meta-analysis %J Depression and anxiety %D 2018 %A Gebara, Marie Anne %A Siripong, Nalyn %A DiNapoli, Elizabeth A. %A Maree, Rachel D. %A Germain, Anne %A Reynolds, Charles F. %A Kasckow, John W. %A Weiss, Patricia M. %A Karp, Jordan F. %V 35 %N 8 %P 717-731 %X BACKGROUND: Insomnia is frequently co-morbid with depression, with a bidirectional relationship between these disorders. There is evidence that insomnia-specific interventions, such as cognitive behavioral therapy for insomnia, may lead to improvements in depression. The purpose of this systematic review and meta-analysis is to determine whether treatment of insomnia leads to improved depression outcomes in individuals with both insomnia and depression.

METHODS: We conduct a systematic review and meta-analysis to explore the effect of treatment for insomnia disorder on depression in patients with both disorders.

RESULTS: Three thousand eight hundred and fifteen studies were reviewed, and 23 studies met inclusion criteria. Although all of the studies suggested a positive clinical effect of insomnia treatment on depression outcomes, most of the results were not statistically significant. Although the interventions and populations were highly variable, the meta-analysis indicates moderate to large effect size (ES) improvement in depression as measured with the Hamilton Depression Rating Scale (ES = -1.29, 95%CI [-2.11, -0.47]) and Beck Depression Inventory (ES = -0.68, 95%CI [-1.29, -0.06]).

CONCLUSIONS: These results support that treating insomnia in patients with depression has a positive effect on mood. Future trials are needed to identify the subtypes of patients whose depression improves during treatment with insomnia-specific interventions, and to identify the mechanisms by which treating insomnia improves mood.

© 2018 Wiley Periodicals, Inc.

Language: en

%G en %I John Wiley and Sons %@ 1091-4269 %U http://dx.doi.org/10.1002/da.22776