%0 Journal Article
%T Longitudinal changes in magnetic resonance spectroscopy in pediatric concussion: a pilot study
%J Frontiers in neurology
%D 2019
%A Meyer, Erin J.
%A Stout, Jeffrey N.
%A Chung, Ai Wern
%A Grant, P. Ellen
%A Mannix, Rebekah
%A Gagoski, Borjan
%V 10
%N 
%P e556-e556
%X <b>Background:</b> Nearly 20% of US adolescents report at least one lifetime concussion. Pathophysiologic models suggest that traumatic biomechanical forces caused by rotational deceleration lead to shear stress, which triggers a neurometabolic cascade beginning with excitotoxicity and leading to significant energy demands and a period of metabolic crisis for the injured brain. Proton magnetic resonance spectroscopy (<sup>1</sup>H MRS) offers a means for non-invasive measurement of neurometabolic changes after concussion. <b>Objective:</b> Describe longitudinal changes in metabolites measured <i>in vivo</i> in the brains of adolescent patients with concussion. <b>Methods:</b> We prospectively recruited 9 patients ages 11 to 20 who presented to a pediatric Emergency Department within 24 h of concussion. Patients underwent MRI scanning within 72 h (acute, <i>n</i> = 8), 2 weeks (subacute, <i>n</i> = 7), and at approximately 1 year (chronic, <i>n</i> = 7). Healthy, age and sex-matched controls were recruited and scanned once (<i>n</i> = 9). <sup>1</sup>H MRS was used to measure N-acetyl-aspartate, choline, creatine, glutamate + glutamine, and myo-inositol concentrations in six regions of interest: left and right frontal white matter, posterior white matter and thalamus. <b>Results:</b> There was a significant increase in total thalamus glutamate+glutamine/choline at the subacute (<i>p</i> = 0.010) and chronic (<i>p</i> = 0.010) time points, and a significant decrease in total white matter myo-inositol/choline (<i>p</i> = 0.030) at the chronic time point as compared to controls. <b>Conclusion:</b> There are no differences in <sup>1</sup>H MRS measurements in the acute concussive period; however, changes in glutamate+glutamine and myo-inositol concentrations detectable by <sup>1</sup>H MRS may develop beyond the acute period.<p /> <p>Language: en</p>
%G en
%I Frontiers Research Foundation
%@ 1664-2295
%U http://dx.doi.org/10.3389/fneur.2019.00556