%0 Journal Article
%T Elevated serum levels of inflammation-related cytokines in mild traumatic brain injury are associated with cognitive performance
%J Frontiers in neurology
%D 2019
%A Sun, Yingxiang
%A Bai, Lijun
%A Niu, Xuan
%A Wang, Zhuonan
%A Yin, Bo
%A Bai, Guanghui
%A Zhang, Danbin
%A Gan, Shuoqiu
%A Sun, Chuanzhu
%A Wang, Shan
%A Zhu, Feng
%A Zhang, Ming
%V 10
%N 
%P e1120-e1120
%X Mild traumatic brain injury (mTBI) is the most common neurological insult and leads to long-lasting cognitive impairments. The immune system modulates brain functions and plays a key role in cognitive deficits, however, the relationship between TBI-induced changes in inflammation-related cytokine levels and cognitive consequences is unclear. This was investigated in the present study in two cohorts of individuals within 1 week of mTBI (<i>n</i> = 52, <i>n</i> = 43) and 54 matched healthy control subjects. Patients with mTBI were also followed up at 1 and 3 months post-injury. Measures included cognitive assessments and a 9-plex panel of serum cytokines including interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12, chemokine ligand 2 (CCL2), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). The contribution of cytokine levels to cognitive function was evaluated by multivariate linear regression analysis. The results showed that serum levels of IL-1β, IL-6, and CCL2 were acutely elevated in mTBI patients relative to controls; CCL2 level was remained high over 3 months whereas IL-1β and IL-6 levels were declined by 3 months post-injury. A high level of CCL2 was associated with greater severity of post-concussion symptoms (which survived in the multiple testing correction); elevated IL-1β was associated with worse working memory in acute phase (which failed in correction); and acute high CCL2 level predicted higher information processing speed at 3 months post-injury (which failed in correction). Thus, acute serum cytokine levels are useful for evaluating post-concussion symptoms and predicting cognitive outcome in participants with mTBI.<br><br>Copyright © 2019 Sun, Bai, Niu, Wang, Yin, Bai, Zhang, Gan, Sun, Wang, Zhu and Zhang.<p /> <p>Language: en</p>
%G en
%I Frontiers Research Foundation
%@ 1664-2295
%U http://dx.doi.org/10.3389/fneur.2019.01120