%0 Journal Article
%T Reduced risk of suicidal behaviors associated with the treatment of hidradenitis suppurativa with tumor necrosis factor (TNF) alpha antagonists: results from the US FDA Adverse Events Reporting System (FAERS) pharmacovigilance database
%J Journal of the European Academy of Dermatology and Venereology
%D 2020
%A Gupta, M. A.
%A Sheridan, A. D.
%A Gupta, A. K.
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, recurrent condition that presents as painful, suppurating lesions in the apocrine gland-bearing skin regions. HS has been associated with increased suicidal behaviors (SB), independent of any treatment. TNF-alpha antagonists are used to treat moderate-to-severe HS and have also been associated with SB, a factor that could confound the decision to use the TNF-α antagonists in the moderately-to-severely affected HS patients, who may already be experiencing increased SB risk. <br><br>OBJECTIVES: To determine presence or absence of a safety signal for SB when HS is treated with TNF-α antagonists. <br><br>METHODS: We calculated the Reporting Odds Ratios (ROR) with 95%CI of SB associated with treatment for HS with TNF-α antagonists versus the reference group of all other treatments for HS in the US Food and Drug Administration pharmacovigilance database from January 1, 2004 -March 31, 2019. A second analysis excluded isotretinoin (which has been used to treat HS and has also been associated with SB) from the reference group. <br><br>RESULTS: There was a signal for decreased risk of SB with TNF-α antagonists (ROR=0.1959, 95% CI 0.1247-0.3079; z=7.071, p<0.0001] versus all other HS treatments; the ROR did not change significantly after isotretinoin was excluded from the reference group. <br><br>CONCLUSIONS: Treatment of HS with TNF-α antagonists is associated with a decreased risk of SB.<br><br>© 2020 European Academy of Dermatology and Venereology.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 0926-9959
%U http://dx.doi.org/10.1111/jdv.16224