%0 Journal Article
%T Childhood maltreatment and clinical severity of treatment-resistant depression in a French cohort of outpatients (FACE-DR): One-year follow-up
%J Depression and anxiety
%D 2020
%A Yrondi, Antoine
%A Aouizerate, Bruno
%A Bennabi, Djamila
%A Richieri, Raphaëlle
%A d'Amato, Thierry
%A Bellivier, Frank
%A Bougerol, Thierry
%A Horn, Mathilde
%A Camus, Vincent
%A Courtet, Philippe
%A Doumy, Olivier
%A Genty, Jean-Baptiste
%A Holtzmann, Jérôme
%A Lançon, Christophe
%A Leboyer, Marion
%A Llorca, Pierre M.
%A Maruani, Julia
%A Moirand, Remi
%A Molière, Fanny
%A Samalin, Ludovic
%A Schmitt, Laurent
%A Stephan, Florian
%A Turecki, Gustavo
%A Vaiva, Guillame
%A Walter, Michel
%A Petrucci, Jean
%A Haffen, Emmanuel
%A El-Hage, Wissam
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: Childhood maltreatment is associated with major depressive disorder (MDD). It not only increases the risk of lifetime MDD, but it also aggravates its course. Among depressed patients, 20-30% of them experience treatment-resistance depression (TRD). We aimed to assess the association between childhood maltreatment, severity of depression in a unipolar TRD sample, and patient outcomes after one-year of follow-up. <br><br>METHODS: Patients were recruited for a prospective cohort from the French network of TRD expert centers. Depressive symptom severity was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR). Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire (CTQ). <br><br>RESULTS: In total, 256 patients filled in the CTQ at baseline between 2012 and 2019. At baseline, the MADRS score was associated with CTQ score (β = .185; p = .004). QIDS was also associated with CTQ scores (β = .27; p < .001). Regarding the different subtypes of childhood maltreatment, MADRS was associated with physical (β = .21; p = .005) and sexual abuse (β = .22; p = .002), while QIDS with physical abuse (β = .304; p < .001) and physical neglect (β = .254; p < .001). However, we did not find any significant association focusing on the other types of traumas. During a 1-year follow-up focusing on remission, CTQ scores (baseline) were less important in remittent patients [n = 38; CTQ score = 39.26 (9.68)] than in nonremittent ones [n = 92; CTQ score = 46.02 (17.53)] (p = .027). There was no significant difference among remitters and nonremitters based on trauma subtypes. At baseline, CTQ scores had a significant influence on remission at 1 year (χ<sup>2</sup> (1) = 5.57; p < .05). We lost this influence adding MADRS scores at baseline in the model (p = .063). <br><br>CONCLUSION: We highlighted a significant association between the severity of depressive disorders and childhood maltreatment in the TRD population. Information about a history of childhood maltreatment helps in identifying individuals who could be less likely to go into remission after treatment.<br><br>© 2020 Wiley Periodicals, Inc.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 1091-4269
%U http://dx.doi.org/10.1002/da.22997