%0 Journal Article
%T Amygdala response to emotional faces in adolescents with persistent post-concussion symptoms
%J Neuroimage: clinical
%D 2020
%A Bohorquez-Montoya, Luisa
%A España, Lezlie Y.
%A Nader, Amy M.
%A Furger, Robyn E.
%A Mayer, Andrew R.
%A Meier, Timothy B.
%V 26
%N 
%P e102217-e102217
%X Approximately 30% of adolescents with concussion develop persistent post-concussion symptoms (PPCS) that include emotional symptoms. Elevated amygdalae reactivity to emotional faces has been reported in a variety of psychopathologies characterized by emotional symptoms overlapping with those in PPCS. We tested the hypothesis that amygdalae reactivity to emotional faces in adolescents with PPCS+ is elevated compared to concussed adolescents without PPCS and healthy controls. Concussed adolescents (ages 14-18) with (PPCS+; n = 23) and without PPCS (PPCS-; n = 13) participated in visits at least 4 weeks post-injury. Adolescents without prior concussion served as controls (HC; n = 15). All participants completed a detailed clinical battery and a common emotional face processing task that involved matching of emotional faces or shapes. Compared to HC and PPCS-, adolescents with PPCS+ had elevated depression symptoms, anhedonia, general psychological symptoms, and anxiety symptoms. Contrary to our hypothesis, PPCS+ had lower amygdalae activity to the emotional faces versus shapes condition relative to HC and a trend for lower activity relative to PPCS-. There was a non-significant inverse association between anhedonia amygdalae activity in adolescents with PPCS. <br><br>RESULTS suggest that adolescents with PPCS have altered amygdalae activity during the processing of emotional face stimuli.<br><br>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 2213-1582
%U http://dx.doi.org/10.1016/j.nicl.2020.102217