%0 Journal Article
%T Long-term risk of hip or forearm fractures in older occasional users of benzodiazepines
%J British journal of clinical pharmacology
%D 2020
%A Carrier, Hélène
%A Cortaredona, Sébastien
%A Philipps, Viviane
%A Jacqmin-Gadda, Hélène
%A Tournier, Marie
%A Verdoux, Helene
%A Verger, Pierre
%V ePub
%N ePub
%P ePub-ePub
%X AIMS: This article sought to study the association between patterns of benzodiazepine (BZD) use and the risk of hip and forearm fractures in people aged 50 and 75 years or more. <br><br>METHODS: In a representative cohort of the French National Health Insurance Fund of individuals aged 50 years or older) (N=106 437), we followed up BZD dispensing (reflecting their patterns of use) and the most frequent fall-related fractures (hip and forearm) for 8 years. We used joint latent class models to simultaneously identify BZD dispensing trajectories and the risk of fractures in the entire cohort and in those 75 years or older). We used a survival model to estimate the adjusted hazard ratios (aHRs) between these trajectories and the risk of fractures. <br><br>RESULTS: In the entire cohort, we identified 5 BZD trajectories: "non-users" (76.7% of the cohort); "occasional users" (15.2%); "decreasing users"(2.6%); "late increasing users" (3.0%); and "early increasing users" (2.4%). Compared with non-users, fracture risk was not increased in either occasional users (aHR = 0.99, 95% CI 0.99-1.00) or in decreasing users (aHR = 0.90, 95% CI 0.74-1.08). It was significantly higher in early increasing users (aHR = 1.86, 95% CI 1.62-2.14) and in late increasing users (aHR = 1.39, 95% CI 1.15-1.60). We observed similar trajectories and risk levels in the people older than 75 years. <br><br>CONCLUSION: Occasional BZD use, which is compatible with current recommendations, was not associated with an excess risk of the most frequent fall-related fractures in people older than 50 or 75 years.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 0306-5251
%U http://dx.doi.org/10.1111/bcp.14307