%0 Journal Article
%T Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder
%J American journal of medical genetics. part B, neuropsychiatric genetics
%D 2007
%A De Luca, Vincenzo
%A Likhodi, Olga
%A Kennedy, James L.
%A Wong, Albert H. C.
%V 144
%N 3
%P 370-374
%X The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression. However, a recent meta-analysis failed to confirm this association. We developed an improved quantitative assay for the measurement of allele-specific expression of the 5-HT2A gene, and find that the ratio of C/T allele expression in the pre-frontal cortex of heterozygous suicide victims (n = 10) was significantly decreased in comparison with the non-suicide group (n = 10) (P = 0.049). Because the 5-HT2A gene is subject to imprinting, the parent-of-origin may affect the inheritance of suicidal behavior. Thus we examined the parental origin of specific alleles for genetic association in a genetic family-based sample of major psychoses in which information on suicidal behavior was available. No association between the 5-HT2A C102T polymorphism and suicidal behavior in major psychoses was detected with the transmission/disequilibrium test (TDT).<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 1552-4841
%U http://dx.doi.org/10.1002/ajmg.b.30458