%0 Journal Article
%T Head injury is associated with tau deposition on PET in MCI and AD patients
%J Alzheimer's and dementia: diagnosis, assessment and disease monitoring
%D 2021
%A Jagust, William J.
%A Wu, Yu-Chien
%A Deardorff, Rachael
%A West, John D.
%A Risacher, Shannon L.
%A McAllister, Thomas W.
%A Apostolova, Liana G.
%A Saykin, Andrew J.
%A Weiner, Michael W.
%A Landau, Susan M.
%A Brosch, Jared R.
%A Farlow, Martin R.
%A Gao, Sujuan
%V 13
%N 1
%P e12230-e12230
%X INTRODUCTION: Head injuries (HI) are a risk factor for dementia, but the underlying etiology is not fully known. Understanding whether tau might mediate this relationship is important. <br><br>METHODS: Cognition and tau deposition were compared between 752 individuals with (impaired, n = 302) or without cognitive impairment (CN, n = 450) with amyloid and [(18)F]flortaucipir positron emission tomography, HI history information, and cognitive testing from the Alzheimer's Disease Neuroimaging Initiative and the Indiana Memory and Aging Study. <br><br>RESULTS: Sixty-three (38 CN, 25 impaired) reported a history of HI. Higher neuropsychiatric scores and poorer memory were observed in those with a history of HI. Tau was higher in individuals with a history of HI, especially those who experienced a loss of consciousness (LOC). <br><br>RESULTS were driven by impaired individuals, especially amyloid beta-positive individuals with history of HI with LOC. <br><br>DISCUSSION: These findings suggest biological changes, such as greater tau, are associated with HI in individuals with cognitive impairment. Small effect sizes were observed; thus, further studies should replicate and extend these results.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 2352-8729
%U http://dx.doi.org/10.1002/dad2.12230