%0 Journal Article
%T Impulsivity in persons with epilepsy: association with seizure severity and suicide risk
%J Epilepsy research
%D 2021
%A Lee, Sang-Ahm
%A Choi, Eun Ju
%A Jeon, Ji-Ye
%A Han, Su-Hyun
%A Kim, Hyun-Woo
%A Lee, Gha-Hyun
%A Ryu, Han Uk
%A Im, Kayeong
%A Yang, Ha-Rin
%V 179
%N 
%P e106825-e106825
%X PURPOSE: Clinical research regarding impulsivity in patients with epilepsy is limited. The present study investigated the associations between impulsivity and seizure-related factors or suicidality in patients with epilepsy, independent of depression and anxiety. <br><br>METHODS: The multicenter study included 146 subjects (63% men). We utilized the Barratt Impulsiveness Scale-11 (BIS-11), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and suicidality module of the Mini International Neuropsychiatric Interview (MINI). Stepwise regression analyses and an analysis of covariance with interaction terms were performed. <br><br>RESULTS: The mean BIS-11 score was 59.3 (SD = 10.7). Psychiatric pathologies, including suicidality, were reported in relatively large proportions of patients, including PHQ-9 score ≥ 10 in 29 (19.9%) patients, GAD-7 score ≥ 7 in 35 (24.0%) patients, and MINI suicidality score ≥ 6 in 15 (10.3%) patients. Stepwise linear regression revealed that BIS-11 score was positively associated with the PHQ-9 scores (p < 0.001), antiseizure medication polytherapy (p < 0.001), use of lamotrigine (p = 0.009), and recurrence of generalized or focal to bilateral tonic clonic seizures (p = 0.010). The coefficient of determination for the model was 0.397. Generalized or focal to bilateral tonic clonic seizure recurrence tended to be positively associated with total BIS-11 scores in men but not in women. In subscale analyses, somewhat different variables were associated with different BIS-11subscales. A trend for a positive association between BIS-11 score and suicidality was found (p = 0.066). <br><br>CONCLUSIONS: This study identified a positive association between clinical seizure severity and impulsivity, and found that this association tended to be sex-specific, occurring only in males. Impulsivity could potentially be weakly associated with suicidality in patients with epilepsy.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0920-1211
%U http://dx.doi.org/10.1016/j.eplepsyres.2021.106825