%0 Journal Article
%T Resting-state functional connectivity patterns associated with childhood maltreatment in a large bicentric cohort of adults with and without major depression
%J Psychological medicine
%D 2022
%A Goltermann, Janik
%A Winter, Nils Ralf
%A Meinert, Susanne
%A Sindermann, Lisa
%A Lemke, Hannah
%A Leehr, Elisabeth J.
%A Grotegerd, Dominik
%A Winter, Alexandra
%A Thiel, Katharina
%A Waltemate, Lena
%A Breuer, Fabian
%A Repple, Jonathan
%A Gruber, Marius
%A Richter, Maike
%A Teckentrup, Vanessa
%A Kroemer, Nils B.
%A Brosch, Katharina
%A Meller, Tina
%A Pfarr, Julia-Katharina
%A Ringwald, Kai Gustav
%A Stein, Frederike
%A Heindel, Walter
%A Jansen, Andreas
%A Kircher, Tilo
%A Nenadic, Igor
%A Dannlowski, Udo
%A Opel, Nils
%A Hahn, Tim
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: Childhood maltreatment (CM) represents a potent risk factor for major depressive disorder (MDD), including poorer treatment response. Altered resting-state connectivity in the fronto-limbic system has been reported in maltreated individuals. However, previous results in smaller samples differ largely regarding localization and direction of effects. <br><br>METHODS: We included healthy and depressed samples [n = 624 participants with MDD; n = 701 healthy control (HC) participants] that underwent resting-state functional MRI measurements and provided retrospective self-reports of maltreatment using the Childhood Trauma Questionnaire. A-priori defined regions of interest [ROI; amygdala, hippocampus, anterior cingulate cortex (ACC)] were used to calculate seed-to-voxel connectivities. <br><br>RESULTS: No significant associations between maltreatment and resting-state connectivity of any ROI were found across MDD and HC participants and no interaction effect with diagnosis became significant. Investigating MDD patients only yielded maltreatment-associated increased connectivity between the amygdala and dorsolateral frontal areas [p(FDR) < 0.001; η(2)(partial) = 0.050; 95%-CI (0.023-0.085)]. This effect was robust across various sensitivity analyses and was associated with concurrent and previous symptom severity. Particularly strong amygdala-frontal associations with maltreatment were observed in acutely depressed individuals [n = 264; p(FDR) < 0.001; η(2)(partial) = 0.091; 95%-CI (0.038-0.166)). Weaker evidence - not surviving correction for multiple ROI analyses - was found for altered supracallosal ACC connectivity in HC individuals associated with maltreatment. <br><br>CONCLUSIONS: The majority of previous resting-state connectivity correlates of CM could not be replicated in this large-scale study. The strongest evidence was found for clinically relevant maltreatment associations with altered adult amygdala-dorsolateral frontal connectivity in depression. Future studies should explore the relevance of this pathway for a maltreated subgroup of MDD patients.<p /> <p>Language: en</p>
%G en
%I Cambridge University Press
%@ 0033-2917
%U http://dx.doi.org/10.1017/S0033291722001623