%0 Journal Article
%T Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort
%J PLoS one
%D 2022
%A Koo, Seul
%A Kim, Ji Yeon
%A Park, Ji Hye
%A Roh, Gu Seob
%A Lim, Nam Kyoo
%A Park, Hyun Young
%A Kim, Won-Ho
%V 17
%N 7
%P e0271291-e0271291
%X BACKGROUND: Alcohol drinking during pregnancy has been well-known to cause the detrimental effects on fetal development; however, the adverse effects of pre-pregnancy drinking are largely unknown. We investigate whether alcohol drinking status before pregnancy is associated with the risk for macrosomia, an offspring's adverse outcome, in a Korean pregnancy registry cohort (n = 4,542) enrolled between 2013 and 2017. <br><br>METHODS: Binge drinking was defined as consuming ≥5 drinks on one occasion and ≥2 times a week, and a total 2,886 pregnant, included in the final statistical analysis, were divided into 3 groups: never, non-binge, and binge drinking. <br><br>RESULTS: The prevalence of macrosomia was higher in binge drinking before pregnancy than those with never or non-binge drinking (7.5% vs. 3.2% or 2.9%, p = 0.002). Multivariable logistic regression analysis demonstrated an independent association between macrosomia and prepregnancy binge drinking after adjusting for other confounders (adjusted odds ratio = 2.29; 95% CI, 1.08-4.86; p = 0.031). The model added binge drinking before pregnancy led to improvement of 10.6% (95% CI, 2.03-19.07; p = 0.0006) in discrimination from traditional risk prediction models. <br><br>CONCLUSION: Together, binge drinking before pregnancy might be an independent risk factor for developing macrosomia. Intensified intervention for drinking alcohol in women who are planning a pregnancy is important and may help prevent macrosomia.<p /> <p>Language: en</p>
%G en
%I Public Library of Science
%@ 1932-6203
%U http://dx.doi.org/10.1371/journal.pone.0271291